The Science
When we are delivering functional food ingredients to where they should be getting, we are addressing the health needs much better.
Nutaria brings targeted functional food for a better nutritional health.
Targeted food supplements unravel a whole new world of possibilities in optimizing nutritional health.
The Science
In a concerted effort to validate the efficacy of our targeted food supplement technology, Nutaria has undertaken rigorous preclinical trials. These studies have been independently conducted by a third-party organization at the renowned Hadassah Medical Center's Biotechnology Hub in Jerusalem.
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Two distinct types of particles were tested in these trials, both consisting of curcumin, a compound known for its therapeutic benefits. The first type consisted solely of curcumin, while the second was an innovative formulation, featuring curcumin encapsulated within a particle coated with caffeine molecules, leveraging the unique binding affinity of caffeine to its target cells.
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Using human neuronal cells as our model, we investigated the interactions of these particles with cells. The preliminary control group, represented in slide one, showcases neuronal DNA in its original state, devoid of any treatment
Figure two portrays the aftermath of treating these cells with commercially available curcumin, devoid of any lipid coating. It was evident that there was negligible absorption of curcumin into the cells, hinting at the limited effectiveness of this approach.
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Figure three introduces a variant of curcumin delivery, the liposomal form. Despite the known benefits of liposomes in enhancing drug delivery, only minimal amounts of curcumin were absorbed by the cells, as indicated by the faint fluorescence.
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The narrative takes a significant turn in figures four and five, which demonstrate the remarkable potential of our targeted nanoparticles. These particles, enriched with curcumin and encapsulated within a caffeine coating, show a markedly different cellular interaction. As neuronal cells naturally express caffeine receptors on their surface, they readily recognize and internalize these caffeine-coated particles.
This advanced interaction facilitates extensive internalization of curcumin into the cells, a notable improvement over previous methods.
Crucially, this caffeine-assisted delivery offers no respite to free radicals and reactive oxygen species, setting the stage for a robust defense mechanism against these damaging entities. This insightful study substantiates the promising potential of Nutaria's targeted food supplement technology, potentially revolutionizing therapeutic strategies in the future.
In parallel to the compelling results obtained from lab testing of our particles on human neuronal cells, we have engaged in an array of comprehensive analytical studies aimed at testing the stability of these particles in varying environments.
These studies scrutinize the behavior of the particles under acidic conditions, akin to the environments of the stomach and bile, as well as under neutral conditions reminiscent of blood plasma.
Moreover, we have performed meticulous analyses to assess the physicochemical attributes of our particles, including size, shape, and electrical charge, ensuring their suitability for oral administration. These aspects are integral to the Chemistry, Manufacturing, and Controls (CMC) phase of our R&D formulation process, ensuring the quality and consistency of our product.
As can be seen below, the particles show promising data and validate their potential as next-generation targeted delivery food supplementation.
While it is imperative to note that more work is necessary to satisfy the stringent regulatory requirements of agencies such as the FDA and FSA, these preliminary findings are indeed promising. They provide a robust foundation for our technology, ushering the way for subsequent developmental stages. The journey toward achieving regulatory approval is intricate and demanding, but these results inspire confidence in the viability and potential of our targeted food supplement technology.